PFK15 [Ligand Id: 9562] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3105836
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3/6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 in Human [ChEMBL: CHEMBL2331053] [GtoPdb: 2937] [UniProtKB: Q16875]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3/6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331053] [GtoPdb: 2937] [UniProtKB: Q16875]
GtoPdb Inhibition of kinase activity in a biochemical assay. - 6.68 pIC50 207 nM IC50 Mol Cancer Ther (2013) 12: 1461-70 [PMID:23674815]
ChEMBL Inhibition of PFKFB3 (unknown origin) B 6.68 pIC50 207 nM IC50 Bioorg Med Chem Lett (2014) 24: 4915-4925 [PMID:25288186]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]