mangiferin [Ligand Id: 13843] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL464825 (Mangiferin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| aldo-keto reductase family 1 member B in Human [GtoPdb: 2768] [UniProtKB: P15121] | ||||||||
| GtoPdb | - | - | 7.27 | pKd | 53.7 | nM | Kd | |
| aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] | ||||||||
| ChEMBL | Inhibition of aldose reductase in rat lens homogenate | B | 5.49 | pIC50 | 3200 | nM | IC50 | J Nat Prod (2003) 66: 1191-1196 [PMID:14510595] |
| Beta-glucuronidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2728] [UniProtKB: P08236] | ||||||||
| ChEMBL | Inhibition of beta-glucuronidase (unknown origin) | B | 4.42 | pIC50 | 38000 | nM | IC50 | Eur J Med Chem (2020) 187: 111921-111921 [PMID:31835168] |
| MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
| ChEMBL | Inhibition of MMP9 in human U2OS cells by peptide microarray-based fluorescence assay | B | 6.6 | pIC50 | 250 | nM | IC50 | J Nat Prod (2022) 85: 2424-2432 [PMID:36122348] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation assay | F | 4.62 | pIC50 | 23800 | nM | IC50 | J Nat Prod (2008) 71: 1887-1890 [PMID:18950229] |
| Sialidase in Clostridium perfringens (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5189] [UniProtKB: P10481] | ||||||||
| ChEMBL | Inhibition of Clostridium perfringens neuraminidase by fluorimetry | B | 4.79 | pIC50 | 16200 | nM | IC50 | Bioorg Med Chem (2009) 17: 2744-2750 [PMID:19285413] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
