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Decarboxylases C
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Overview
The decarboxylases generate CO2 and the indicated products from acidic substrates, requiring pyridoxal 5-phosphate or pyruvic acid as a co-factor.
Enzymes
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GAD1 (Glutamic acid decarboxylase 1) C Show summary »« Hide summary
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GAD2 (Glutamic acid decarboxylase 2) C Show summary »« Hide summary
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HDC (Histidine decarboxylase) C Show summary »« Hide summary
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ADC (L-Arginine decarboxylase ) C Show summary »« Hide summary
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AADC (L-Aromatic amino-acid decarboxylase )
C
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MLYCD (Malonyl-CoA decarboxylase)
C
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ODC (Ornithine decarboxylase)
C
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PSDC (Phosphatidylserine decarboxylase ) C Show summary »« Hide summary
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SAMDC (S-Adenosylmethionine decarboxylase ) C Show summary »« Hide summary
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References
1. Coleman CS, Hu G, Pegg AE. (2004) Putrescine biosynthesis in mammalian tissues. Biochem J, 379 (Pt 3): 849-55. [PMID:14763899]
2. Daidone F, Montioli R, Paiardini A, Cellini B, Macchiarulo A, Giardina G, Bossa F, Borri Voltattorni C. (2012) Identification by virtual screening and in vitro testing of human DOPA decarboxylase inhibitors. PLoS ONE, 7 (2): e31610. [PMID:22384042]
3. Garbarg M, Barbin G, Rodergas E, Schwartz JC. (1980) Inhibition of histamine synthesis in brain by alpha-fluoromethylhistidine, a new irreversible inhibitor: in vitro and in vivo studies. J Neurochem, 35 (5): 1045-52. [PMID:7452304]
4. Pajunen AE, Hietala OA, Baruch-Virransalo EL, Piha RS. (1979) The effect of DL-allylglycine on polyamine and GABA metabolism in mouse brain. J Neurochem, 32 (5): 1401-8. [PMID:438812]
5. Qu N, Ignatenko NA, Yamauchi P, Stringer DE, Levenson C, Shannon P, Perrin S, Gerner EW. (2003) Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine. Biochem J, 375 (Pt 2): 465-70. [PMID:12859253]
6. Saha AK, Schwarsin AJ, Roduit R, Masse F, Kaushik V, Tornheim K, Prentki M, Ruderman NB. (2000) Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-beta -D-ribofuranoside. J Biol Chem, 275 (32): 24279-83. [PMID:10854420]
7. Stanek J, Caravatti G, Frei J, Furet P, Mett H, Schneider P, Regenass U. (1993) 4-Amidinoindan-1-one 2'-amidinohydrazone: a new potent and selective inhibitor of S-Adenosylmethionine decarboxylase. J Med Chem, 36 (15): 2168-71. [PMID:8340919]
8. Stanek J, Frei J, Mett H, Schneider P, Regenass U. (1992) 2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity. J Med Chem, 35 (8): 1339-44. [PMID:1573631]
9. Wu JY, Matsuda T, Roberts E. (1973) Purification and characterization of glutamate decarboxylase from mouse brain. J Biol Chem, 248 (9): 3029-34. [PMID:4700449]
10. Zhu MY, Iyo A, Piletz JE, Regunathan S. (2004) Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine. Biochim Biophys Acta, 1670 (2): 156-64. [PMID:14738999]
How to cite this family page
Database page citation:
Decarboxylases. Accessed on 17/01/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=256.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.
