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Target not currently curated in GtoImmuPdb
Target id: 1275
Nomenclature: Malonyl-CoA decarboxylase
Abbreviated Name: MLYCD
Family: Decarboxylases
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 493 | 16q23.3 | MLYCD | malonyl-CoA decarboxylase | |
| Mouse | - | 492 | 8 E1 | Mlycd | malonyl-CoA decarboxylase | |
| Rat | - | 492 | 19q12 | Mlycd | malonyl-CoA decarboxylase | |
| Previous and Unofficial Names |
| MCD | malonyl-CoA decarboxylase, mitochondrial |
| Database Links |
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| Alphafold | O95822 (Hs), Q99J39 (Mm), Q920F5 (Rn) |
| BRENDA | 4.1.1.9 |
| ChEMBL Target | CHEMBL4698 (Hs), CHEMBL1255162 (Mm) |
| Ensembl Gene | ENSG00000103150 (Hs), ENSMUSG00000074064 (Mm), ENSRNOG00000014522 (Rn) |
| Entrez Gene | 23417 (Hs), 56690 (Mm), 85239 (Rn) |
| Human Protein Atlas | ENSG00000103150 (Hs) |
| KEGG Enzyme | 4.1.1.9 |
| KEGG Gene | hsa:23417 (Hs), mmu:56690 (Mm), rno:85239 (Rn) |
| OMIM | 606761 (Hs) |
| Pharos | O95822 (Hs) |
| UniProtKB | O95822 (Hs), Q99J39 (Mm), Q920F5 (Rn) |
| Wikipedia | MLYCD (Hs) |
| Enzyme Reaction |
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Download all structure-activity data for this target as a CSV file 
| Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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1. Tang H, Yan Y, Feng Z, de Jesus RK, Yang L, Levorse DA, Owens KA, Akiyama TE, Bergeron R, Castriota GA et al.. (2010) Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities. Bioorg Med Chem Lett, 20 (20): 6088-92. [PMID:20832306]
Decarboxylases: Malonyl-CoA decarboxylase. Last modified on 10/07/2018. Accessed on 10/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1275.
