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Ornithine decarboxylase

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Target not currently curated in GtoImmuPdb

Target id: 1276

Nomenclature: Ornithine decarboxylase

Abbreviated Name: ODC

Family: Decarboxylases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 461 2p25.1 ODC1 ornithine decarboxylase 1
Mouse - 461 12 8.11 cM Odc1 ornithine decarboxylase, structural 1
Rat - 461 6q16 Odc1 ornithine decarboxylase 1
Previous and Unofficial Names Click here for help
ODC | RNODC | ornithine decarboxylase, structural 1
Database Links Click here for help
Alphafold P11926 (Hs), P00860 (Mm), P09057 (Rn)
BRENDA 4.1.1.17
CATH/Gene3D 3.20.20.10, 2.40.37.10
ChEMBL Target CHEMBL1869 (Hs), CHEMBL2840 (Mm), CHEMBL3511 (Rn)
Ensembl Gene ENSG00000115758 (Hs), ENSMUSG00000011179 (Mm), ENSRNOG00000005424 (Rn)
Entrez Gene 4953 (Hs), 18263 (Mm), 24609 (Rn)
Human Protein Atlas ENSG00000115758 (Hs)
KEGG Enzyme 4.1.1.17
KEGG Gene hsa:4953 (Hs), mmu:18263 (Mm), rno:24609 (Rn)
OMIM 165640 (Hs)
Pharos P11926 (Hs)
UniProtKB P11926 (Hs), P00860 (Mm), P09057 (Rn)
Wikipedia ODC1 (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human ornithine decarboxylase at 2.1 angstoms resolution
PDB Id:  1D7K
Resolution:  2.1Å
Species:  Human
References:  1
Enzyme Reaction Click here for help
EC Number: 4.1.1.17
Substrates and Reaction Kinetics Click here for help
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
L-ornithine Substrate is endogenous in the given species Hs - -
Cofactors Click here for help
Cofactor Species Comments Reference
pyridoxal 5-phosphate None

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
eflornithine Small molecule or natural product Approved drug Primary target of this compound Hs Inhibition 4.9 pKd 2
⤷ pKd 4.9 (Kd 1.3x10-5 M) [2]
APA Small molecule or natural product Ligand has a PDB structure Hs Inhibition 7.5 pIC50 3
⤷ pIC50 7.5 (IC50 3.5x10-8 M) [3]
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Colorectal cancer
Disease Ontology: DOID:9256
OMIM: 114500
Role:  A polymorphism in ODC1 is associated with reduced risk of colonic adenoma recurrence.
References:  4

References

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1. Almrud JJ, Oliveira MA, Kern AD, Grishin NV, Phillips MA, Hackert ML. (2000) Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding. J Mol Biol, 295 (1): 7-16. [PMID:10623504]

2. Qu N, Ignatenko NA, Yamauchi P, Stringer DE, Levenson C, Shannon P, Perrin S, Gerner EW. (2003) Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine. Biochem J, 375 (Pt 2): 465-70. [PMID:12859253]

3. Stanek J, Frei J, Mett H, Schneider P, Regenass U. (1992) 2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity. J Med Chem, 35 (8): 1339-44. [PMID:1573631]

4. Zell JA, Ziogas A, Ignatenko N, Honda J, Qu N, Bobbs AS, Neuhausen SL, Gerner EW, Anton-Culver H. (2009) Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival. Clin Cancer Res, 15 (19): 6208-16. [PMID:19789310]

How to cite this page

Decarboxylases: Ornithine decarboxylase. Last modified on 16/04/2015. Accessed on 10/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1276.