CYP1A1

Target id: 1318

Nomenclature: CYP1A1

Family: CYP1 family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - CYP1A1 cytochrome P450 family 1 subfamily A member 1
Mouse - - Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1
Rat - - Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1
Previous and Unofficial Names
Aryl hydrocarbon hydroxylase
CP11
AHH
AHRR
Cyp45c
Cypc45c
cytochrome P450 1A1
microsomal monooxygenase
xenobiotic monooxygenase
cytochrome P450 subfamily I, polypeptide 1
cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1
cytochrome P450, family 1, subfamily A, polypeptide 1
cytochrome P450, family 1, subfamily a, polypeptide 1
cytochrome P450
Database Links
BRENDA
Ensembl Gene
Entrez Gene
ExplorEnz
GeneCards
GenitoUrinary Development Molecular Anatomy Project
Human Protein Reference Database
InterPro
KEGG Enzyme
KEGG Gene
NeXtProt
OMIM
PhosphoSitePlus
TreeFam
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.14.1.1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
chrysin Hs Inhibition 7.4 pKi 1
pKi 7.4 (Ki 4.2x10-8 M) [1]
5H3'FPE Hs Inhibition 7.4 pIC50 2
pIC50 7.4 (IC50 4.3x10-8 M) [2]

References

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1. Androutsopoulos VP, Papakyriakou A, Vourloumis D, Spandidos DA. (2011) Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. Bioorg. Med. Chem.19 (9): 2842-9. [PMID:21482471]

2. Liu J, Taylor SF, Dupart PS, Arnold CL, Sridhar J, Jiang Q, Wang Y, Skripnikova EV, Zhao M, Foroozesh M. (2013) Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1. J. Med. Chem.56 (10): 4082-92. [PMID:23600958]

How to cite this page

CYP1 family: CYP1A1. Last modified on 17/09/2015. Accessed on 02/12/2016. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1318.