CYP2C8

Target id: 1325

Nomenclature: CYP2C8

Family: CYP2 family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for CYP2C8 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - CYP2C8 cytochrome P450 family 2 subfamily C member 8
Previous and Unofficial Names
cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8 | cytochrome P450, family 2, subfamily C, polypeptide 8
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.14.14.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
phenelzine Hs Inhibition 5.1 pKi 2
pKi 5.1 (Ki 7.266x10-6 M) [2]
compound 51 [Crosignani et al., 2011] Hs Inhibition 7.4 pIC50 1
pIC50 7.4 (IC50 4.3x10-8 M) [1]

References

Show »

1. Crosignani S, Jorand-Lebrun C, Campbell G, Pretre A, Grippi-Vallotton, T, Quattropani, A, Bouscary-Desforges G, Bombrun A, Missotten, M, Humbert Y et al.. (2011) Discovery of a Novel Series of CRTH2 (DP2) Receptor Antagonists Devoid of Carboxylic Acids. ACS Med Chem Lett2: 938-942.

2. Fontana E, Dansette PM, Poli SM. (2005) Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr. Drug Metab.6 (5): 413-54. [PMID:16248836]

How to cite this page

CYP2 family: CYP2C8. Last modified on 16/09/2015. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1325.