AKR1C3 | Prostaglandin synthases | IUPHAR/BPS Guide to PHARMACOLOGY


Target id: 1382

Nomenclature: AKR1C3

Family: Prostaglandin synthases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for AKR1C3 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - AKR1C3 aldo-keto reductase family 1 member C3
Mouse - - Akr1c18 aldo-keto reductase family 1, member C18
Rat - - Akr1c3 aldo-keto reductase family 1, member C3
Previous and Unofficial Names
Aldo-keto reductase family 1 member C3 | prostaglandin F synthase | 17β-HSD 5 | 17β-hydroxysteroid dehydrogenase type 5 | 3α-hydroxysteroid dehydrogenase type 2 | dihydrodiol dehydrogenase 3 | dihydrodiol dehydrogenase type I | PGFS | hydroxysteroid (17-beta) dehydrogenase 5 | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | Akr1c18 | aldo-keto reductase family 1 member C18 | HSD1 | aldo-keto reductase family 1, member C3 | aldo-keto reductase family 1
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction
EC Number: PGD2 + NADP+ = PGF + NADPH + H+
EC Number:
EC Number:
EC Number:
EC Number:
Inhibitors (Human)
flufenamic acid, indomethacin, flavonoids  [1,3]

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
tolfenamic acid Hs Inhibition 8.1 pKi 2
pKi 8.1 (Ki 8x10-9 M) [2]


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1. Matsuura K, Shiraishi H, Hara A, Sato K, Deyashiki Y, Ninomiya M, Sakai S. (1998) Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity. J. Biochem., 124 (5): 940-6. [PMID:9792917]

2. Qiu W, Zhou M, Mazumdar M, Azzi A, Ghanmi D, Luu-The V, Labrie F, Lin SX. (2007) Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase. J. Biol. Chem., 282 (11): 8368-79. [PMID:17166832]

3. Skarydová L, Zivná L, Xiong G, Maser E, Wsól V. (2009) AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids. Chem. Biol. Interact., 178 (1-3): 138-44. [PMID:19007764]

How to cite this page

Prostaglandin synthases: AKR1C3. Last modified on 15/09/2015. Accessed on 20/09/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1382.