GPR171

Target id: 143

Nomenclature: GPR171

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for GPR171 in GtoImmuPdb

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 319 3q25.1 GPR171 G protein-coupled receptor 171 2
Mouse 7 319 3 D Gpr171 G protein-coupled receptor 171
Rat 7 326 2q31 Gpr171 G protein-coupled receptor 171
Previous and Unofficial Names
G-protein coupled receptor H963 | platelet activating receptor homolog
Database Links
Specialist databases
GPCRDB gp171_human (Hs)
Other databases
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Agonist Comments
GPR171 has been shown to be activated by endogenous peptide BigLEN. This receptor-peptide interaction is believed to be involved in regulating feeding and metabolism responses [1].
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  I283V
Global MAF (%):  5
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 2|3|13|1
Minor allele count:  C=0.047/103
SNP accession: 
Validation:  1000 Genomes, HapMap, Frequency
General Comments
GPR171 is excluded as a candidate gene of Usher syndrome Type 3 [3].

References

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1. Gomes I, Aryal DK, Wardman JH, Gupta A, Gagnidze K, Rodriguiz RM, Kumar S, Wetsel WC, Pintar JE, Fricker LD et al.. (2013) GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. Proc. Natl. Acad. Sci. U.S.A.,  [Epub ahead of print]. [PMID:24043826]

2. Jacobs KA, Collins-Racie LA, Colbert M, Duckett M, Golden-Fleet M, Kelleher K, Kriz R, LaVallie ER, Merberg D, Spaulding V et al.. (1997) A genetic selection for isolating cDNAs encoding secreted proteins. Gene198 (1-2): 289-96. [PMID:9370294]

3. Joensuu T, Hämäläinen R, Yuan B, Johnson C, Tegelberg S, Gasparini P, Zelante L, Pirvola U, Pakarinen L, Lehesjoki AE et al.. (2001) Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3. Am. J. Hum. Genet.69 (4): 673-84. [PMID:11524702]

Contributors

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How to cite this page

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: GPR171. Last modified on 30/07/2015. Accessed on 24/11/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=143.