Methionyl aminopeptidase 1

Target id: 1572

Nomenclature: Methionyl aminopeptidase 1

Family: M24: Methionyl aminopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Methionyl aminopeptidase 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 386 4q23 METAP1 methionyl aminopeptidase 1
Mouse - 386 3 G3 Metap1 methionyl aminopeptidase 1
Rat - 386 2q44 Metap1 methionyl aminopeptidase 1
Previous and Unofficial Names
MAP1A | Peptidase M | methionine aminopeptidase 1 | MetAP1A
Database Links
Specialist databases
MEROPS M24.017 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.11.3
EC Number: 3.4.11.18

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 14 [PMID: 23634668] Hs Inhibition 7.0 pEC50 1
pEC50 7.0 (EC50 9.3x10-8 M) [1]
Description: In the presence of Co.

References

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1. Zhang F, Bhat S, Gabelli SB, Chen X, Miller MS, Nacev BA, Cheng YL, Meyers DJ, Tenney K, Shim JS et al.. (2013) Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells. J. Med. Chem.56 (10): 3996-4016. [PMID:23634668]

How to cite this page

M24: Methionyl aminopeptidase: Methionyl aminopeptidase 1. Last modified on 14/07/2015. Accessed on 11/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1572.