Carboxypeptidase B2 (plasma)

Target id: 1594

Nomenclature: Carboxypeptidase B2 (plasma)

Family: M14: Carboxypeptidase A

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Carboxypeptidase B2 (plasma) in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 423 13q14.11 CPB2 carboxypeptidase B2
Mouse - 422 14 D2 Cpb2 carboxypeptidase B2 (plasma)
Rat - 422 15q11 Cpb2 carboxypeptidase B2
Previous and Unofficial Names
CPU | PCPB | TAFI | carboxypeptidase B2 (plasma, carboxypeptidase U) | carboxypeptidase R | thrombin-activatable fibrinolysis inhibitor | CPR | carboxypeptidase B2 (plasma)
Database Links
Specialist databases
MEROPS M14.009 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.17.20

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 4 [PMID: 19954973] Hs Inhibition 8.5 pKi 3
pKi 8.5 (Ki 3.5x10-9 M) [3]
SQ-24,798 Hs Inhibition 8.4 pKi 2
pKi 8.4 (Ki 4x10-9 M) [2]
UK-396,082 Hs Inhibition 8.0 pKi 2
pKi 8.0 (Ki 1x10-8 M) [2]
compound 3 [PMID: 14640538] Hs Inhibition 6.7 pIC50 1
pIC50 6.7 (IC50 2x10-7 M) [1]

References

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1. Barrow JC, Nantermet PG, Stauffer SR, Ngo PL, Steinbeiser MA, Mao SS, Carroll SS, Bailey C, Colussi D, Bosserman M et al.. (2003) Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J. Med. Chem.46 (25): 5294-7. [PMID:14640538]

2. Bunnage ME, Blagg J, Steele J, Owen DR, Allerton C, McElroy AB, Miller D, Ringer T, Butcher K, Beaumont K et al.. (2007) Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. J. Med. Chem.50 (24): 6095-103. [PMID:17990866]

3. Owen DR, Bull DJ, Bunnage ME, Glossop MS, Maguire RJ, Strang RS. (2010) Oxygenated analogues of UK-396082 as inhibitors of activated thrombin activatable fibrinolysis inhibitor. Bioorg. Med. Chem. Lett.20 (1): 92-6. [PMID:19954973]

How to cite this page

M14: Carboxypeptidase A: Carboxypeptidase B2 (plasma). Last modified on 29/07/2015. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1594.