Carboxypeptidase B2 (plasma) | M14: Carboxypeptidase A | IUPHAR/BPS Guide to PHARMACOLOGY

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Carboxypeptidase B2 (plasma)

Target not currently curated in GtoImmuPdb

Target id: 1594

Nomenclature: Carboxypeptidase B2 (plasma)

Family: M14: Carboxypeptidase A

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 423 13q14.11 CPB2 carboxypeptidase B2
Mouse - 422 14 D2 Cpb2 carboxypeptidase B2 (plasma)
Rat - 422 15q11 Cpb2 carboxypeptidase B2
Previous and Unofficial Names
CPU | PCPB | TAFI | carboxypeptidase B2 (plasma, carboxypeptidase U) | carboxypeptidase R | thrombin-activatable fibrinolysis inhibitor | CPR | carboxypeptidase B2 (plasma)
Database Links
Specialist databases
MEROPS M14.009 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 4 [PMID: 19954973] Hs Inhibition 8.5 pKi 3
pKi 8.5 (Ki 3.5x10-9 M) [3]
SQ-24,798 Hs Inhibition 8.4 pKi 2
pKi 8.4 (Ki 4x10-9 M) [2]
UK-396,082 Hs Inhibition 8.0 pKi 2
pKi 8.0 (Ki 1x10-8 M) [2]
compound 3 [PMID: 14640538] Hs Inhibition 6.7 pIC50 1
pIC50 6.7 (IC50 2x10-7 M) [1]


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1. Barrow JC, Nantermet PG, Stauffer SR, Ngo PL, Steinbeiser MA, Mao SS, Carroll SS, Bailey C, Colussi D, Bosserman M et al.. (2003) Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J. Med. Chem., 46 (25): 5294-7. [PMID:14640538]

2. Bunnage ME, Blagg J, Steele J, Owen DR, Allerton C, McElroy AB, Miller D, Ringer T, Butcher K, Beaumont K et al.. (2007) Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. J. Med. Chem., 50 (24): 6095-103. [PMID:17990866]

3. Owen DR, Bull DJ, Bunnage ME, Glossop MS, Maguire RJ, Strang RS. (2010) Oxygenated analogues of UK-396082 as inhibitors of activated thrombin activatable fibrinolysis inhibitor. Bioorg. Med. Chem. Lett., 20 (1): 92-6. [PMID:19954973]

How to cite this page

M14: Carboxypeptidase A: Carboxypeptidase B2 (plasma). Last modified on 29/07/2015. Accessed on 24/02/2020. IUPHAR/BPS Guide to PHARMACOLOGY,