Carboxypeptidase N, polypeptide 1

Target id: 1597

Nomenclature: Carboxypeptidase N, polypeptide 1

Family: M14: Carboxypeptidase A

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Carboxypeptidase N, polypeptide 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 458 10q24.2 CPN1 carboxypeptidase N subunit 1
Mouse - 457 19 D2 Cpn1 carboxypeptidase N, polypeptide 1
Rat - - Cpn1 carboxypeptidase N subunit 1
Previous and Unofficial Names
anaphylatoxin inactivator | arginine carboxypeptidase | carboxypeptidase K | kininase I | lysine carboxypeptidase | carboxypeptidase N catalytic chain | Cpn | carboxypeptidase N
Database Links
Specialist databases
MEROPS M14.004 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
SQ-24,798 Hs Inhibition 8.7 pKi 2
pKi 8.7 (Ki 2x10-9 M) [2]
compound 3 [PMID: 14640538] Hs Inhibition 7.8 pIC50 1
pIC50 7.8 (IC50 1.7x10-8 M) [1]
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
C3ar1tm1Raw|Cpn1tm1Raw C3ar1tm1Raw/C3ar1tm1Raw,Cpn1tm1Raw/Cpn1tm1Raw
B6.129-C3ar1 Cpn1
MGI:1097680  MGI:2135874  MP:0005088 increased acute inflammation PMID: 19414808 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Carboxypeptidase N deficiency
OMIM: 212070


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1. Barrow JC, Nantermet PG, Stauffer SR, Ngo PL, Steinbeiser MA, Mao SS, Carroll SS, Bailey C, Colussi D, Bosserman M et al.. (2003) Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J. Med. Chem.46 (25): 5294-7. [PMID:14640538]

2. Bunnage ME, Blagg J, Steele J, Owen DR, Allerton C, McElroy AB, Miller D, Ringer T, Butcher K, Beaumont K et al.. (2007) Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. J. Med. Chem.50 (24): 6095-103. [PMID:17990866]

How to cite this page

M14: Carboxypeptidase A: Carboxypeptidase N, polypeptide 1. Last modified on 29/07/2015. Accessed on 19/03/2018. IUPHAR/BPS Guide to PHARMACOLOGY,