Carboxypeptidase N, polypeptide 1 | M14: Carboxypeptidase A | IUPHAR/BPS Guide to PHARMACOLOGY

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Carboxypeptidase N, polypeptide 1

Target not currently curated in GtoImmuPdb

Target id: 1597

Nomenclature: Carboxypeptidase N, polypeptide 1

Family: M14: Carboxypeptidase A

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 458 10q24.2 CPN1 carboxypeptidase N subunit 1
Mouse - 457 19 D2 Cpn1 carboxypeptidase N, polypeptide 1
Rat - - Cpn1 carboxypeptidase N subunit 1
Previous and Unofficial Names
anaphylatoxin inactivator | arginine carboxypeptidase | carboxypeptidase K | kininase I | lysine carboxypeptidase | carboxypeptidase N catalytic chain | Cpn | carboxypeptidase N
Database Links
Specialist databases
MEROPS M14.004 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
SQ-24,798 Hs Inhibition 8.7 pKi 2
pKi 8.7 (Ki 2x10-9 M) [2]
compound 3 [PMID: 14640538] Hs Inhibition 7.8 pIC50 1
pIC50 7.8 (IC50 1.7x10-8 M) [1]
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
C3ar1tm1Raw|Cpn1tm1Raw C3ar1tm1Raw/C3ar1tm1Raw,Cpn1tm1Raw/Cpn1tm1Raw
B6.129-C3ar1 Cpn1
MGI:1097680  MGI:2135874  MP:0005088 increased acute inflammation PMID: 19414808 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Carboxypeptidase N deficiency
OMIM: 212070


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1. Barrow JC, Nantermet PG, Stauffer SR, Ngo PL, Steinbeiser MA, Mao SS, Carroll SS, Bailey C, Colussi D, Bosserman M et al.. (2003) Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J. Med. Chem., 46 (25): 5294-7. [PMID:14640538]

2. Bunnage ME, Blagg J, Steele J, Owen DR, Allerton C, McElroy AB, Miller D, Ringer T, Butcher K, Beaumont K et al.. (2007) Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. J. Med. Chem., 50 (24): 6095-103. [PMID:17990866]

How to cite this page

M14: Carboxypeptidase A: Carboxypeptidase N, polypeptide 1. Last modified on 29/07/2015. Accessed on 24/02/2020. IUPHAR/BPS Guide to PHARMACOLOGY,