Folate hydrolase (prostate-specific membrane antigen) 1

Target id: 1606

Nomenclature: Folate hydrolase (prostate-specific membrane antigen) 1

Family: M28: Aminopeptidase Y

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Folate hydrolase (prostate-specific membrane antigen) 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 750 11p11.2 FOLH1 folate hydrolase 1
Mouse - 791 7 D1-D2 Folh1 folate hydrolase 1
Rat - 752 1q32 Folh1 folate hydrolase 1
Previous and Unofficial Names
GCP2 | GCPII | NAALAD1 | PSM | glutamate carboxylase II | glutamate carboxypeptidase II | FGCP | folylpoly-gamma-glutamate carboxypeptidase | glutamate carboxypeptidase 2 | membrane glutamate carboxypeptidase | mGCP | NAALADase I | N-acetylated-alpha-linked acidic dipeptidase I | pteroylpoly-gamma-glutamate carboxypeptidase | prostate-specific membrane antigen | FOLH | folate hydrolase (prostate-specific membrane antigen) 1
Database Links
Specialist databases
MEROPS M28.010 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 8d [PMID: 15027864] Hs Inhibition 8.5 pKi 1
pKi 8.5 (Ki 3x10-9 M) [1]
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
capromab Hs Binding - -


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1. Kozikowski AP, Zhang J, Nan F, Petukhov PA, Grajkowska E, Wroblewski JT, Yamamoto T, Bzdega T, Wroblewska B, Neale JH. (2004) Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents. J. Med. Chem.47 (7): 1729-38. [PMID:15027864]

How to cite this page

M28: Aminopeptidase Y: Folate hydrolase (prostate-specific membrane antigen) 1. Last modified on 27/10/2015. Accessed on 21/03/2018. IUPHAR/BPS Guide to PHARMACOLOGY,