Folate hydrolase (prostate-specific membrane antigen) 1

Target id: 1606

Nomenclature: Folate hydrolase (prostate-specific membrane antigen) 1

Family: M28: Aminopeptidase Y

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Folate hydrolase (prostate-specific membrane antigen) 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 750 11p11.2 FOLH1 folate hydrolase 1
Mouse - 791 7 D1-D2 Folh1 folate hydrolase 1
Rat - 752 1q32 Folh1 folate hydrolase 1
Previous and Unofficial Names
GCP2 | GCPII | NAALAD1 | PSM | glutamate carboxylase II | glutamate carboxypeptidase II | FGCP | folylpoly-gamma-glutamate carboxypeptidase | glutamate carboxypeptidase 2 | membrane glutamate carboxypeptidase | mGCP | NAALADase I | N-acetylated-alpha-linked acidic dipeptidase I | pteroylpoly-gamma-glutamate carboxypeptidase | prostate-specific membrane antigen | FOLH | folate hydrolase (prostate-specific membrane antigen) 1
Database Links
Specialist databases
MEROPS M28.010 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.17.21

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 8d [PMID: 15027864] Hs Inhibition 8.5 pKi 1
pKi 8.5 (Ki 3x10-9 M) [1]
Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
capromab Hs Binding - -

References

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1. Kozikowski AP, Zhang J, Nan F, Petukhov PA, Grajkowska E, Wroblewski JT, Yamamoto T, Bzdega T, Wroblewska B, Neale JH. (2004) Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents. J. Med. Chem., 47 (7): 1729-38. [PMID:15027864]

How to cite this page

M28: Aminopeptidase Y: Folate hydrolase (prostate-specific membrane antigen) 1. Last modified on 27/10/2015. Accessed on 16/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1606.