Folate hydrolase (prostate-specific membrane antigen) 1 | M28: Aminopeptidase Y | IUPHAR/BPS Guide to PHARMACOLOGY

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Folate hydrolase (prostate-specific membrane antigen) 1

Target not currently curated in GtoImmuPdb

Target id: 1606

Nomenclature: Folate hydrolase (prostate-specific membrane antigen) 1

Family: M28: Aminopeptidase Y

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 750 11p11.2 FOLH1 folate hydrolase 1
Mouse - 791 7 D1-D2 Folh1 folate hydrolase 1
Rat - 752 1q32 Folh1 folate hydrolase 1
Previous and Unofficial Names
GCP2 | GCPII | NAALAD1 | PSM | glutamate carboxylase II | glutamate carboxypeptidase II | FGCP | folylpoly-gamma-glutamate carboxypeptidase | glutamate carboxypeptidase 2 | membrane glutamate carboxypeptidase | mGCP | NAALADase I | N-acetylated-alpha-linked acidic dipeptidase I | pteroylpoly-gamma-glutamate carboxypeptidase | prostate-specific membrane antigen | FOLH | folate hydrolase (prostate-specific membrane antigen) 1
Database Links
Specialist databases
MEROPS M28.010 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 8d [PMID: 15027864] Hs Inhibition 8.5 pKi 1
pKi 8.5 (Ki 3x10-9 M) [1]
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
capromab Hs Binding - -


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1. Kozikowski AP, Zhang J, Nan F, Petukhov PA, Grajkowska E, Wroblewski JT, Yamamoto T, Bzdega T, Wroblewska B, Neale JH. (2004) Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents. J. Med. Chem., 47 (7): 1729-38. [PMID:15027864]

How to cite this page

M28: Aminopeptidase Y: Folate hydrolase (prostate-specific membrane antigen) 1. Last modified on 27/10/2015. Accessed on 28/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY,