Endothelin-converting enzyme 2

Target id: 1616

Nomenclature: Endothelin-converting enzyme 2

Abbreviated Name: ECE2

Family: M13: Neprilysin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Endothelin-converting enzyme 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 883 3q27.1 ECE2 endothelin converting enzyme 2
Mouse - 910 16 B1 Ece2 endothelin converting enzyme 2
Rat - 754 11q23 Ece2 endothelin-converting enzyme 2
Database Links
Specialist databases
MEROPS M13.003 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.24.71
Endogenous substrates (Human)
endothelin-1 (EDN1, P05305), endothelin-2 (EDN2, P20800), endothelin-3 (EDN3, P14138)

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
S136492 Hs Inhibition 5.3 pIC50 1
pIC50 5.3 (IC50 4.63x10-6 M) [1]
compound 1 [PMID: 18507370] Hs Inhibition 5.2 pIC50 1
pIC50 5.2 (IC50 6.42x10-6 M) [1]

References

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1. Gagnidze K, Sachchidanand, Rozenfeld R, Mezei M, Zhou MM, Devi LA. (2008) Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2. J. Med. Chem.51 (12): 3378-87. [PMID:18507370]

How to cite this page

M13: Neprilysin: Endothelin-converting enzyme 2. Last modified on 28/07/2015. Accessed on 19/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1616.