Endothelin-converting enzyme 2

Target id: 1616

Nomenclature: Endothelin-converting enzyme 2

Abbreviated Name: ECE2

Family: M13: Neprilysin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Endothelin-converting enzyme 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 883 3q27.1 ECE2 endothelin converting enzyme 2
Mouse - 910 16 B1 Ece2 endothelin converting enzyme 2
Rat - 754 11q23 Ece2 endothelin-converting enzyme 2
Database Links
Specialist databases
MEROPS M13.003 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:
Endogenous substrates (Human)
endothelin-1 (EDN1, P05305), endothelin-2 (EDN2, P20800), endothelin-3 (EDN3, P14138)

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
S136492 Hs Inhibition 5.3 pIC50 1
pIC50 5.3 (IC50 4.63x10-6 M) [1]
compound 1 [PMID: 18507370] Hs Inhibition 5.2 pIC50 1
pIC50 5.2 (IC50 6.42x10-6 M) [1]


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1. Gagnidze K, Sachchidanand, Rozenfeld R, Mezei M, Zhou MM, Devi LA. (2008) Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2. J. Med. Chem.51 (12): 3378-87. [PMID:18507370]

How to cite this page

M13: Neprilysin: Endothelin-converting enzyme 2. Last modified on 28/07/2015. Accessed on 18/03/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1616.