Caspase 2

Target id: 1618

Nomenclature: Caspase 2

Family: C14: Caspase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Caspase 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 452 7q34-q35 CASP2 caspase 2
Mouse - 452 6 B2.1 Casp2 caspase 2
Rat - 452 4q23 Casp2 caspase 2
Previous and Unofficial Names
protein phosphatase 1, regulatory subunit 57 | protease ICH-1 | ICH1 | NEDD2 | neural precursor cell expressed developmentally down-regulated protein 2 | PPP1R57 | caspase 2, apoptosis-related cysteine peptidase
Database Links
Specialist databases
MEROPS C14.006 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.22.55

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 4 [PMID: 12408711] Hs Inhibition 6.0 pKi 1
pKi 6.0 (Ki 9.6x10-7 M) [1]
Z-VDVAD-FMK Hs Inhibition - - 2
[2]

References

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1. Choong IC, Lew W, Lee D, Pham P, Burdett MT, Lam JW, Wiesmann C, Luong TN, Fahr B, DeLano WL et al.. (2002) Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J. Med. Chem.45 (23): 5005-22. [PMID:12408711]

2. Gamen S, Anel A, Pérez-Galán P, Lasierra P, Johnson D, Piñeiro A, Naval J. (2000) Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells. Exp. Cell Res.258 (1): 223-35. [PMID:10912804]

How to cite this page

C14: Caspase: Caspase 2. Last modified on 22/07/2015. Accessed on 24/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1618.