Caspase 5 | C14: Caspase | IUPHAR/BPS Guide to PHARMACOLOGY

Caspase 5

Target id: 1621

Nomenclature: Caspase 5

Family: C14: Caspase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Caspase 5 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 434 11q22.2-q22.3 CASP5 caspase 5
Previous and Unofficial Names
ICH-3 protease | TY protease | ICE(rel)III | caspase 5, apoptosis-related cysteine peptidase
Database Links
Specialist databases
MEROPS C14.008 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
M826 Hs Inhibition 6.7 pIC50 2
pIC50 6.7 (IC50 2x10-7 M) [2]
uracil 20 Hs Inhibition 5.5 pIC50 1
pIC50 5.5 (IC50 2.98x10-6 M) [1]
Description: IC50 in a biochemical assay.
Z-WEHD-FMK Hs Inhibition - - 3


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1. Fournier J-FF, Clary L, Chambon S, Dumais L, Harris CSS, Millois-Barbuis C, Pierre R, Talano S, Thoreau E et al.. (2018) Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne. Journal of Medicinal Chemistry, Just Accepted Manuscript.

2. Han Y, Giroux A, Colucci J, Bayly CI, Mckay DJ, Roy S, Xanthoudakis S, Vaillancourt J, Rasper DM, Tam J et al.. (2005) Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg. Med. Chem. Lett., 15 (4): 1173-80. [PMID:15686936]

3. Naito T, Yokogawa T, Kim HS, Futagami M, Wataya Y, Matsuda A, Fukushima M, Kitade Y, Sasaki T. (2002) Anticancer mechanisms of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl) cytosine (ECyd, TAS-106). Nucleic Acids Res. Suppl., (2): 241-2. [PMID:12903195]

How to cite this page

C14: Caspase: Caspase 5. Last modified on 13/04/2018. Accessed on 20/09/2018. IUPHAR/BPS Guide to PHARMACOLOGY,