Caspase 5

Target id: 1621

Nomenclature: Caspase 5

Family: C14: Caspase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Caspase 5 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 434 11q22.2-q22.3 CASP5 caspase 5
Previous and Unofficial Names
ICH-3 protease | TY protease | ICE(rel)III | caspase 5, apoptosis-related cysteine peptidase
Database Links
Specialist databases
MEROPS C14.008 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.22.58

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
M826 Hs Inhibition 6.7 pIC50 1
pIC50 6.7 (IC50 2x10-7 M) [1]
Z-WEHD-FMK Hs Inhibition - - 2
[2]

References

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1. Han Y, Giroux A, Colucci J, Bayly CI, Mckay DJ, Roy S, Xanthoudakis S, Vaillancourt J, Rasper DM, Tam J et al.. (2005) Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg. Med. Chem. Lett.15 (4): 1173-80. [PMID:15686936]

2. Naito T, Yokogawa T, Kim HS, Futagami M, Wataya Y, Matsuda A, Fukushima M, Kitade Y, Sasaki T. (2002) Anticancer mechanisms of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl) cytosine (ECyd, TAS-106). Nucleic Acids Res. Suppl.,  (2): 241-2. [PMID:12903195]

How to cite this page

C14: Caspase: Caspase 5. Last modified on 27/07/2015. Accessed on 11/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1621.