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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 434 | 11q22.3 | CASP5 | caspase 5 | |
| Previous and Unofficial Names |
| ICH-3 protease | TY protease | ICE(rel)III | caspase 5, apoptosis-related cysteine peptidase |
| Database Links |
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| Specialist databases | |
| MEROPS | C14.008 (Hs) |
| Other databases | |
| Alphafold | P51878 (Hs) |
| BRENDA | 3.4.22.58 |
| ChEMBL Target | CHEMBL3131 (Hs) |
| Ensembl Gene | ENSG00000137757 (Hs) |
| Entrez Gene | 838 (Hs) |
| Human Protein Atlas | ENSG00000137757 (Hs) |
| KEGG Enzyme | 3.4.22.58 |
| KEGG Gene | hsa:838 (Hs) |
| OMIM | 602665 (Hs) |
| Pharos | P51878 (Hs) |
| RefSeq Nucleotide | NM_001136110 (Hs), NM_001136109 (Hs), NM_001136112 (Hs), NM_004347 (Hs) |
| RefSeq Protein | NP_001129581 (Hs), NP_001129584 (Hs), NP_004338 (Hs), NP_001129582 (Hs) |
| UniProtKB | P51878 (Hs) |
| Wikipedia | CASP5 (Hs) |
| Enzyme Reaction |
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Download all structure-activity data for this target as a CSV file 
| Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Immunopharmacology Comments |
| Recognition of cytoplasmic lipopolysaccharide (LPS) by Inflammatory caspases including caspases-4 and -5 leads to pyroptosis and secretion of inflammatory mediators [4-5]. |
| Immuno Process Associations | ||
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1. Fournier JF, Clary L, Chambon S, Dumais L, Harris CS, Millois C, Pierre R, Talano S, Thoreau É, Aubert J et al.. (2018) Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne. J Med Chem, 61 (9): 4030-4051. [PMID:29648825]
2. Han Y, Giroux A, Colucci J, Bayly CI, Mckay DJ, Roy S, Xanthoudakis S, Vaillancourt J, Rasper DM, Tam J et al.. (2005) Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg Med Chem Lett, 15 (4): 1173-80. [PMID:15686936]
3. Naito T, Yokogawa T, Kim HS, Futagami M, Wataya Y, Matsuda A, Fukushima M, Kitade Y, Sasaki T. (2002) Anticancer mechanisms of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl) cytosine (ECyd, TAS-106). Nucleic Acids Res Suppl, (2): 241-2. [PMID:12903195]
4. Shi J, Gao W, Shao F. (2017) Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death. Trends Biochem Sci, 42 (4): 245-254. [PMID:27932073]
5. Shi J, Zhao Y, Wang Y, Gao W, Ding J, Li P, Hu L, Shao F. (2014) Inflammatory caspases are innate immune receptors for intracellular LPS. Nature, 514 (7521): 187-92. [PMID:25119034]
C14: Caspase: Caspase 5. Last modified on 11/02/2019. Accessed on 04/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1621.
target has curated data in GtoImmuPdb
