Caspase 9

Target id: 1625

Nomenclature: Caspase 9

Family: C14: Caspase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Caspase 9 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 416 1p36.21 CASP9 caspase 9
Mouse - 454 4 E1 Casp9 caspase 9
Rat - 454 5q36 Casp9 caspase 9
Previous and Unofficial Names
APAF-3 | apoptotic protease Mch-6 | ICE-LAP6 | ICE-like apoptotic protease 6 | protein phosphatase 1, regulatory subunit 56 | apoptotic protease activating factor 3 | MCH6 | PPP1R56
Database Links
Specialist databases
MEROPS C14.010 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
caspase 9 Hs - -
PARP Hs - -
pro-caspase 3 Hs - -
pro-caspase 6 Hs - -
pro-caspase 7 Hs - -

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
isatin sulfonamide 34 [PMID: 11384246] Hs Inhibition 6.9 pKi 1
pKi 6.9 (Ki 1.2x10-7 M) [1]
Z-LEHD-FMK Hs Inhibition - - 2


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1. Lee D, Long SA, Murray JH, Adams JL, Nuttall ME, Nadeau DP, Kikly K, Winkler JD, Sung CM, Ryan MD et al.. (2001) Potent and selective nonpeptide inhibitors of caspases 3 and 7. J. Med. Chem., 44 (12): 2015-26. [PMID:11384246]

2. Mocanu MM, Baxter GF, Yellon DM. (2000) Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury. Br. J. Pharmacol., 130 (2): 197-200. [PMID:10807653]

How to cite this page

C14: Caspase: Caspase 9. Last modified on 22/07/2015. Accessed on 19/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY,