Caspase 9

Target id: 1625

Nomenclature: Caspase 9

Family: C14: Caspase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Caspase 9 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 416 1p36.21 CASP9 caspase 9
Mouse - 454 4 E1 Casp9 caspase 9
Rat - 454 5q36 Casp9 caspase 9
Previous and Unofficial Names
APAF-3 | apoptotic protease Mch-6 | ICE-LAP6 | ICE-like apoptotic protease 6 | protein phosphatase 1, regulatory subunit 56 | apoptotic protease activating factor 3 | MCH6 | PPP1R56
Database Links
Specialist databases
MEROPS C14.010 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.22.62
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
caspase 9 Hs - -
PARP Hs - -
pro-caspase 3 Hs - -
pro-caspase 6 Hs - -
pro-caspase 7 Hs - -

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
isatin sulfonamide 34 [PMID: 11384246] Hs Inhibition 6.9 pKi 1
pKi 6.9 (Ki 1.2x10-7 M) [1]
Z-LEHD-FMK Hs Inhibition - - 2
[2]

References

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1. Lee D, Long SA, Murray JH, Adams JL, Nuttall ME, Nadeau DP, Kikly K, Winkler JD, Sung CM, Ryan MD et al.. (2001) Potent and selective nonpeptide inhibitors of caspases 3 and 7. J. Med. Chem.44 (12): 2015-26. [PMID:11384246]

2. Mocanu MM, Baxter GF, Yellon DM. (2000) Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury. Br. J. Pharmacol.130 (2): 197-200. [PMID:10807653]

How to cite this page

C14: Caspase: Caspase 9. Last modified on 22/07/2015. Accessed on 19/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1625.