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Caspase 9

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Target not currently curated in GtoImmuPdb

Target id: 1625

Nomenclature: Caspase 9

Family: C14: Caspase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 416 1p36.21 CASP9 caspase 9
Mouse - 454 4 E1 Casp9 caspase 9
Rat - 454 5q36 Casp9 caspase 9
Previous and Unofficial Names Click here for help
APAF-3 | apoptotic protease Mch-6 | ICE-LAP6 | ICE-like apoptotic protease 6 | protein phosphatase 1, regulatory subunit 56 | apoptotic protease activating factor 3 | MCH6 | PPP1R56
Database Links Click here for help
Specialist databases
MEROPS C14.010 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.22.62
Substrates and Reaction Kinetics Click here for help
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
caspase 9 Substrate is endogenous in the given species Hs - -
PARP Substrate is endogenous in the given species Hs - -
pro-caspase 3 Substrate is endogenous in the given species Hs - -
pro-caspase 6 Substrate is endogenous in the given species Hs - -
pro-caspase 7 Substrate is endogenous in the given species Hs - -

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
isatin sulfonamide 34 [PMID: 11384246] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.9 pKi 1
pKi 6.9 (Ki 1.2x10-7 M) [1]
Z-LEHD-FMK Peptide Hs Inhibition - - 2
[2]
Immuno Process Associations
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes
GO:0030220 platelet formation TAS

References

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1. Lee D, Long SA, Murray JH, Adams JL, Nuttall ME, Nadeau DP, Kikly K, Winkler JD, Sung CM, Ryan MD et al.. (2001) Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem, 44 (12): 2015-26. [PMID:11384246]

2. Mocanu MM, Baxter GF, Yellon DM. (2000) Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury. Br J Pharmacol, 130 (2): 197-200. [PMID:10807653]

How to cite this page

C14: Caspase: Caspase 9. Last modified on 22/07/2015. Accessed on 18/06/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1625.