MMP16

Target id: 1640

Nomenclature: MMP16

Family: M10: Matrix metallopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for MMP16 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 607 8q21 MMP16 matrix metallopeptidase 16
Mouse - 607 4 A3 Mmp16 matrix metallopeptidase 16
Rat - 547 5q13 Mmp16 matrix metallopeptidase 16
Previous and Unofficial Names
MMP- X2 | membrane-type matrix metalloproteinase 3 | MT3MMP | MTMMP3 | Membrane type 3-MMP | matrix metallopeptidase 16 (membrane-inserted)
Database Links
Specialist databases
MEROPS M10.016 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
SL422 Hs Inhibition 7.5 pKi 2
pKi 7.5 (Ki 3.5x10-8 M) [2]
ilomastat Hs Inhibition 8.1 pIC50 1
pIC50 8.1 (IC50 8x10-9 M) [1]
Inhibitor Comments
SL422 is a broad-spectrum inhibitor of MMP enzymes [2].

References

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1. Ma D, Wu W, Yang G, Li J, Li J, Ye Q. (2004) Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. Bioorg. Med. Chem. Lett.14 (1): 47-50. [PMID:14684295]

2. Xue CB, Voss ME, Nelson DJ, Duan JJ, Cherney RJ, Jacobson IC, He X, Roderick J, Chen L, Corbett RL et al.. (2001) Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J. Med. Chem.44 (16): 2636-60. [PMID:11472217]

How to cite this page

M10: Matrix metallopeptidase: MMP16. Last modified on 16/03/2017. Accessed on 16/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1640.