ADAM9

Target id: 1657

Nomenclature: ADAM9

Family: M12: Astacin/Adamalysin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for ADAM9 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 819 8p11.23 ADAM9 ADAM metallopeptidase domain 9
Mouse - 845 8 A2 Adam9 a disintegrin and metallopeptidase domain 9 (meltrin gamma)
Rat - 845 16q12.4 Adam9 ADAM metallopeptidase domain 9
Previous and Unofficial Names
cellular disintegrin-related protein | myeloma cell metalloproteinase | cone rod dystrophy 9 | disintegrin and metalloproteinase domain-containing protein 9 | CORD9 | MCMP | MDC9 | Mltng
Database Links
Specialist databases
MEROPS M12.209 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.24.-

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
ilomastat Hs Inhibition 9.0 pIC50 1
pIC50 9.0 (IC50 1x10-9 M) [1]
Description: Measured in an in vitro assay.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Cone-rod dystrophy 9; CORD9
Synonyms: Cone rod dystrophy [Orphanet: ORPHA1872] [Disease Ontology: DOID:0050572]
Disease Ontology: DOID:0050572
OMIM: 612775
Orphanet: ORPHA1872

References

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1. Oh M, Im I, Lee YJ, Kim YH, Yoon JH, Park HG, Higashiyama S, Kim YC, Park WJ. (2004) Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors. Bioorg. Med. Chem. Lett., 14 (24): 6071-4. [PMID:15546732]

How to cite this page

M12: Astacin/Adamalysin: ADAM9. Last modified on 29/07/2015. Accessed on 21/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1657.