Target id: 1657

Nomenclature: ADAM9

Family: M12: Astacin/Adamalysin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for ADAM9 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 819 8p11.23 ADAM9 ADAM metallopeptidase domain 9
Mouse - 845 8 A2 Adam9 a disintegrin and metallopeptidase domain 9 (meltrin gamma)
Rat - 845 16q12.4 Adam9 ADAM metallopeptidase domain 9
Previous and Unofficial Names
cellular disintegrin-related protein | myeloma cell metalloproteinase | cone rod dystrophy 9 | disintegrin and metalloproteinase domain-containing protein 9 | CORD9 | MCMP | MDC9 | Mltng
Database Links
Specialist databases
MEROPS M12.209 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
ilomastat Hs Inhibition 9.0 pIC50 1
pIC50 9.0 (IC50 1x10-9 M) [1]
Description: Measured in an in vitro assay.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Cone-rod dystrophy 9; CORD9
Synonyms: Cone rod dystrophy [Orphanet: ORPHA1872] [Disease Ontology: DOID:0050572]
Disease Ontology: DOID:0050572
OMIM: 612775
Orphanet: ORPHA1872


Show »

1. Oh M, Im I, Lee YJ, Kim YH, Yoon JH, Park HG, Higashiyama S, Kim YC, Park WJ. (2004) Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors. Bioorg. Med. Chem. Lett.14 (24): 6071-4. [PMID:15546732]

How to cite this page

M12: Astacin/Adamalysin: ADAM9. Last modified on 29/07/2015. Accessed on 20/03/2018. IUPHAR/BPS Guide to PHARMACOLOGY,