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ADAM9

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Target not currently curated in GtoImmuPdb

Target id: 1657

Nomenclature: ADAM9

Family: M12: Astacin/Adamalysin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 819 8p11.22 ADAM9 ADAM metallopeptidase domain 9
Mouse 1 845 8 13.7 cM Adam9 a disintegrin and metallopeptidase domain 9 (meltrin gamma)
Rat - 845 16q12.4 Adam9 ADAM metallopeptidase domain 9
Previous and Unofficial Names Click here for help
cellular disintegrin-related protein | myeloma cell metalloproteinase | cone rod dystrophy 9 | disintegrin and metalloproteinase domain-containing protein 9 | CORD9 | MCMP | MDC9 | Mltng
Database Links Click here for help
Specialist databases
MEROPS M12.209 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ilomastat Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 9.0 pIC50 1
pIC50 9.0 (IC50 1x10-9 M) [1]
Description: Measured in an in vitro assay.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0042117 monocyte activation IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0034612 response to tumor necrosis factor IDA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0042117 monocyte activation IMP
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Cone-rod dystrophy 9; CORD9
Synonyms: Cone rod dystrophy [Orphanet: ORPHA1872] [Disease Ontology: DOID:0050572]
Disease Ontology: DOID:0050572
OMIM: 612775
Orphanet: ORPHA1872

References

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1. Oh M, Im I, Lee YJ, Kim YH, Yoon JH, Park HG, Higashiyama S, Kim YC, Park WJ. (2004) Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors. Bioorg Med Chem Lett, 14 (24): 6071-4. [PMID:15546732]

How to cite this page

M12: Astacin/Adamalysin: ADAM9. Last modified on 29/07/2015. Accessed on 15/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1657.