Target id: 1674

Nomenclature: ADAMTS1

Family: M12: Astacin/Adamalysin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for ADAMTS1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 967 21q21.3 ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif 1
Mouse - 968 16 C3-C5 Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif
Rat - 967 11q11-q22 Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif
Previous and Unofficial Names
C3-C5 | METH1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | ADAM metallopeptidase with thrombospondin type 1 motif
Database Links
Specialist databases
MEROPS M12.222 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 12c [PMID: 16516466] Hs Inhibition 6.1 pKi 1
pKi 6.1 (Ki 7.76x10-7 M) [1]


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1. Gilmore JL, King BW, Harris C, Maduskuie T, Mercer SE, Liu RQ, Covington MB, Qian M, Ribadeneria MD, Vaddi K et al.. (2006) Synthesis and structure-activity relationship of a novel, achiral series of TNF-alpha converting enzyme inhibitors. Bioorg. Med. Chem. Lett.16 (10): 2699-704. [PMID:16516466]

How to cite this page

M12: Astacin/Adamalysin: ADAMTS1. Last modified on 28/07/2015. Accessed on 24/02/2018. IUPHAR/BPS Guide to PHARMACOLOGY,