ADAMTS1

Target id: 1674

Nomenclature: ADAMTS1

Family: M12: Astacin/Adamalysin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for ADAMTS1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 967 21q21.3 ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif 1
Mouse - 968 16 C3-C5 Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
Rat - 967 11q11-q22 Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
Previous and Unofficial Names
C3-C5 | METH1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | ADAM metallopeptidase with thrombospondin type 1 motif
Database Links
Specialist databases
MEROPS M12.222 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 12c [PMID: 16516466] Hs Inhibition 6.1 pKi 1
pKi 6.1 (Ki 7.76x10-7 M) [1]

References

Show »

1. Gilmore JL, King BW, Harris C, Maduskuie T, Mercer SE, Liu RQ, Covington MB, Qian M, Ribadeneria MD, Vaddi K et al.. (2006) Synthesis and structure-activity relationship of a novel, achiral series of TNF-alpha converting enzyme inhibitors. Bioorg. Med. Chem. Lett.16 (10): 2699-704. [PMID:16516466]

How to cite this page

M12: Astacin/Adamalysin: ADAMTS1. Last modified on 28/07/2015. Accessed on 20/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1674.