Interleukin-2 receptor subunit β | IL-2 receptor family | IUPHAR/BPS Guide to PHARMACOLOGY

Interleukin-2 receptor subunit β

Target id: 1696

Nomenclature: Interleukin-2 receptor subunit β

Family: IL-2 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-2 receptor subunit β has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interleukin-2 receptor
Interleukin-15 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 551 22q12.3 IL2RB interleukin 2 receptor subunit beta
Mouse 1 539 Il2rb interleukin 2 receptor, beta chain
Rat 1 537 Il2rb interleukin 2 receptor subunit beta
Previous and Unofficial Names
CD122 | IL15RB | interleukin 15 receptor, beta | high affinity IL-2 receptor subunit beta | IL-2R subunit beta | IL-15 receptor beta chain | IL-2/15Rbeta | interleukin 2 receptor
Database Links
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
IL2RB is a ligand binding component of the IL-2R and is required to elevate ligand affinity. It also a component of the IL-15R.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0004911 interleukin-2 receptor activity IDA
GO:0019221 cytokine-mediated signaling pathway IDA
GO:0035723 interleukin-15-mediated signaling pathway TAS

How to cite this page

IL-2 receptor family: Interleukin-2 receptor subunit β. Last modified on 28/03/2017. Accessed on 23/09/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1696.