Interleukin-11 receptor, α subunit

Target id: 1709

Nomenclature: Interleukin-11 receptor, α subunit

Family: IL-6 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-11 receptor, α subunit has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interleukin-11 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 422 9p13 IL11RA interleukin 11 receptor subunit alpha
Mouse 1 432 4 21.94 cM Il11ra1 interleukin 11 receptor
Rat 1 431 5q22 Il11ra1 interleukin 11 receptor subunit alpha 1
Previous and Unofficial Names
Il11ra | NR1 | interleukin 11 receptor, alpha | interleukin 11 receptor
Database Links
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
UniProtKB
Wikipedia
Agonist Comments
Interleukin-11 receptor, α subunit is the primary target of the approved drug oprelvekin, a recombinant form of IL-11.
Immunopharmacology Comments
This is the ligand-binding component of the functional receptor for interleukin 11.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  cytokine receptor activity (GO:0004896) IEA
References: 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Craniosynostosis and dental anomalies
OMIM: 614188
Orphanet: ORPHA284149

How to cite this page

IL-6 receptor family: Interleukin-11 receptor, α subunit. Last modified on 07/04/2017. Accessed on 13/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1709.