Interleukin-1 receptor-like 1

Target id: 1735

Nomenclature: Interleukin-1 receptor-like 1

Family: Immunoglobulin-like family of IL-1 receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-1 receptor-like 1 has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interleukin-33 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 556 02q12.1 IL1RL1 interleukin 1 receptor like 1 4
Mouse 1 567 Il1rl1 interleukin 1 receptor-like 1
Rat 1 566 Il1rl1 interleukin 1 receptor-like 1
Previous and Unofficial Names
DER4 | IL33R | ST2 | ST2L | FIT1 | Fos-responsive gene 1 | Ly84 | ST2V
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
IL1RL1 (ST2) is the ligand binding subunit of the functional receptor for IL-33. It is mainly expressed on mast cells, eosinophils and other immune cells [2]. The ST2/IL-33 axis is recognized as playing an important role in the development/exacerbation of IgE-dependent inflammation such as asthma and atopic dermatitis [1,3]. Blockade of ST2 (and/or IL-33; see our comment regarding investigational anti-IL-33 mAb AMG-282) represent potential novel mechanisms for pharmaceutical intervention to suppress allergy and mast cell-eosinophil interplay.
Immuno Cell Type Associations
Immuno Cell Type:  Mast cells
Cell Ontology Term:  
Comment: 
References:  2
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  interleukin-33 receptor activity (GO:0002114) IEA
cytokine receptor activity (GO:0004896) TAS
interleukin-1 receptor activity (GO:0004908) IEA
negative regulation of interferon-gamma production (GO:0032689) IEA
positive regulation of interleukin-5 production (GO:0032754) IEA
positive regulation of chemokine secretion (GO:0090197) IEA
References: 
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of macrophage activation (GO:0043032) IEA
positive regulation of inflammatory response (GO:0050729) IEA
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  negative regulation of T-helper 1 type immune response (GO:0002826) IEA
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  negative regulation of T-helper 1 type immune response (GO:0002826) IEA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  negative regulation of T-helper 1 type immune response (GO:0002826) IEA
positive regulation of macrophage activation (GO:0043032) IEA
positive regulation of inflammatory response (GO:0050729) IEA
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of chemokine secretion (GO:0090197) IEA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  positive regulation of macrophage activation (GO:0043032) IEA
References: 

References

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1. Bandara G, Beaven MA, Olivera A, Gilfillan AM, Metcalfe DD. (2015) Activated mast cells synthesize and release soluble ST2-a decoy receptor for IL-33. Eur. J. Immunol.45 (11): 3034-44. [PMID:26256265]

2. Gangwar RS, Landolina N, Arpinati L, Levi-Schaffer F. (2017) Mast cell and eosinophil surface receptors as targets for anti-allergic therapy. Pharmacol. Ther.170: 37-63. [PMID:27773785]

3. Hsu CL, Neilsen CV, Bryce PJ. (2010) IL-33 is produced by mast cells and regulates IgE-dependent inflammation. PLoS ONE5 (8): e11944. [PMID:20689814]

4. Tominaga S, Yokota T, Yanagisawa K, Tsukamoto T, Takagi T, Tetsuka T. (1992) Nucleotide sequence of a complementary DNA for human ST2. Biochim. Biophys. Acta1171 (2): 215-8. [PMID:1482686]

How to cite this page

Immunoglobulin-like family of IL-1 receptors: Interleukin-1 receptor-like 1. Last modified on 22/03/2017. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1735.