Interleukin-1 receptor-like 1

Target id: 1735

Nomenclature: Interleukin-1 receptor-like 1

Family: Immunoglobulin-like family of IL-1 receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-1 receptor-like 1 has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interleukin-33 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 556 02q12.1 IL1RL1 interleukin 1 receptor like 1 4
Mouse 1 567 Il1rl1 interleukin 1 receptor-like 1
Rat 1 566 Il1rl1 interleukin 1 receptor-like 1
Previous and Unofficial Names
DER4 | IL33R | ST2 | ST2L | FIT1 | Fos-responsive gene 1 | Ly84 | ST2V
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
IL1RL1 (ST2) is the ligand binding subunit of the functional receptor for IL-33. It is mainly expressed on mast cells, eosinophils and other immune cells [2]. The ST2/IL-33 axis is recognized as playing an important role in the development/exacerbation of IgE-dependent inflammation such as asthma and atopic dermatitis [1,3]. Blockade of ST2 (and/or IL-33; see our comment regarding investigational anti-IL-33 mAb AMG-282) represent potential novel mechanisms for pharmaceutical intervention to suppress allergy and mast cell-eosinophil interplay.
Cell Type Associations
Immuno Cell Type:  Mast cells
References:  2
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 6 GO processes
GO:0004896 cytokine receptor activity TAS
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GO:0002114 interleukin-33 receptor activity IEA
GO:0004908 interleukin-1 receptor activity IEA
GO:0032689 negative regulation of interferon-gamma production IEA
GO:0032754 positive regulation of interleukin-5 production IEA
GO:0090197 positive regulation of chemokine secretion IEA
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes, IEA only
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GO:0043032 positive regulation of macrophage activation IEA
GO:0050729 positive regulation of inflammatory response IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0002826 negative regulation of T-helper 1 type immune response IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0002826 negative regulation of T-helper 1 type immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002826 negative regulation of T-helper 1 type immune response IEA
GO:0043032 positive regulation of macrophage activation IEA
GO:0050729 positive regulation of inflammatory response IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0090197 positive regulation of chemokine secretion IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0043032 positive regulation of macrophage activation IEA

References

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1. Bandara G, Beaven MA, Olivera A, Gilfillan AM, Metcalfe DD. (2015) Activated mast cells synthesize and release soluble ST2-a decoy receptor for IL-33. Eur. J. Immunol., 45 (11): 3034-44. [PMID:26256265]

2. Gangwar RS, Landolina N, Arpinati L, Levi-Schaffer F. (2017) Mast cell and eosinophil surface receptors as targets for anti-allergic therapy. Pharmacol. Ther., 170: 37-63. [PMID:27773785]

3. Hsu CL, Neilsen CV, Bryce PJ. (2010) IL-33 is produced by mast cells and regulates IgE-dependent inflammation. PLoS ONE, 5 (8): e11944. [PMID:20689814]

4. Tominaga S, Yokota T, Yanagisawa K, Tsukamoto T, Takagi T, Tetsuka T. (1992) Nucleotide sequence of a complementary DNA for human ST2. Biochim. Biophys. Acta, 1171 (2): 215-8. [PMID:1482686]

How to cite this page

Immunoglobulin-like family of IL-1 receptors: Interleukin-1 receptor-like 1. Last modified on 22/03/2017. Accessed on 16/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1735.