Interleukin-17 receptor D

Target id: 1741

Nomenclature: Interleukin-17 receptor D

Family: IL-17 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-17 receptor D has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 739 03p14.3 IL17RD interleukin 17 receptor D
Mouse 1 738 Il17rd interleukin 17 receptor D
Rat - - Il17rd interleukin 17 receptor D
Previous and Unofficial Names
SEF | IL17RLM
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Immunopharmacology Comments
IL17RD acts as an inhibitor of proinflammatory cytokine signaling (by limiting NF-κB translocation to the nucleus) [1], and has been reported as a feedback antagonist of receptor tyrosine kinase (RTK) signaling [3], and as a tumor suppressor gene [2,4].
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  interleukin-17 receptor activity (GO:0030368) IBA
References: 

References

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1. Fuchs Y, Brunwasser M, Haif S, Haddad J, Shneyer B, Goldshmidt-Tran O, Korsensky L, Abed M, Zisman-Rozen S, Koren L et al.. (2012) Sef is an inhibitor of proinflammatory cytokine signaling, acting by cytoplasmic sequestration of NF-κB. Dev. Cell23 (3): 611-23. [PMID:22975329]

2. Murphy T, Darby S, Mathers ME, Gnanapragasam VJ. (2010) Evidence for distinct alterations in the FGF axis in prostate cancer progression to an aggressive clinical phenotype. J. Pathol.220 (4): 452-60. [PMID:19960500]

3. Ron D, Fuchs Y, Chorev DS. (2008) Know thy Sef: a novel class of feedback antagonists of receptor tyrosine kinase signaling. Int. J. Biochem. Cell Biol.40 (10): 2040-52. [PMID:18450498]

4. Zisman-Rozen S, Fink D, Ben-Izhak O, Fuchs Y, Brodski A, Kraus MH, Bejar J, Ron D. (2007) Downregulation of Sef, an inhibitor of receptor tyrosine kinase signaling, is common to a variety of human carcinomas. Oncogene26 (41): 6093-8. [PMID:17420726]

How to cite this page

IL-17 receptor family: Interleukin-17 receptor D. Last modified on 07/04/2017. Accessed on 22/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1741.