phosphatidylinositol 3-kinase catalytic subunit type 3

Target id: 2152

Nomenclature: phosphatidylinositol 3-kinase catalytic subunit type 3

Abbreviated Name: VPS34

Family: Phosphatidylinositol 3-kinase family, Phosphatidylinositol kinases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for phosphatidylinositol 3-kinase catalytic subunit type 3 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 887 18q12.3 PIK3C3 phosphatidylinositol 3-kinase catalytic subunit type 3
Mouse - 887 18 B1 Pik3c3 phosphatidylinositol 3-kinase catalytic subunit type 3
Rat - 887 18 p12 Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3
Previous and Unofficial Names
catalytic phosphatidylinositol 3-kinase 3 | phosphatidylinositol 3-kinase | Phosphatidylinositol 3-kinase p100 subunit | phosphoinositide-3-kinase, class 3 | PI3K type 3 | PI-3K Vps34p | PI3-kinase type 3 | ptdIns-3-kinase type 3 | phosphatidylinositol 3-kinase, catalytic subunit type 3
Database Links
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Human PIK3C3 crystal structure
Resolution:  2.8Å
Species:  Human
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human PIK3C3 in complex with 3-[4-(4-Morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol
PDB Id:  3LS8
Resolution:  2.25Å
Species:  Human
Image of receptor 3D structure from RCSB PDB
Description:  The crystal structure of Human VPS34 in complex with PIK-III
PDB Id:  4PH4
Ligand:  PIK-III
Resolution:  2.8Å
Species:  Human
References:  4
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
SAR405 Hs Inhibition 8.8 pKd 6
pKd 8.8 (Kd 1.52x10-9 M) [6]
compound 82 [PMID: 21332118] Hs Inhibition 7.5 pKi 3
pKi 7.5 (Ki 3.1x10-8 M) [3]
VPS34-IN-1 Hs Inhibition 8.4 pIC50 7
pIC50 8.4 (IC50 4x10-9 M) [7]
torin 2 Hs Inhibition 8.1 pIC50 5
pIC50 8.1 (IC50 8.58x10-9 M) [5]
PIK-III Hs Inhibition 7.7 pIC50 4
pIC50 7.7 (IC50 1.8x10-8 M) [4]
compound 28 [PMID: 24387221] Hs Inhibition 6.7 pIC50 2
pIC50 6.7 (IC50 1.83x10-7 M) [2]
General Comments
VPS34 is the only Class III PI 3-kinase (a lipid kinase) identified. Human VPS34 is ubiquitously expressed and is the enzymatic component of a multiprotein complex. VPS34 substrate specificity is limited to phosphatidylinositol. Mammalian VPS34 may be involved in nutrient sensing and autophagy, which permits modulation of cellular activty in response to nutritional changes [1].


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1. Backer JM. (2008) The regulation and function of Class III PI3Ks: novel roles for Vps34. Biochem. J.410 (1): 1-17. [PMID:18215151]

2. Certal V, Carry JC, Halley F, Virone-Oddos A, Thompson F, Filoche-Rommé B, El-Ahmad Y, Karlsson A, Charrier V, Delorme C et al.. (2014) Discovery and optimization of pyrimidone indoline amide PI3Kβ inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers. J. Med. Chem.57 (3): 903-20. [PMID:24387221]

3. D'Angelo ND, Kim TS, Andrews K, Booker SK, Caenepeel S, Chen K, D'Amico D, Freeman D, Jiang J, Liu L et al.. (2011) Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors. J. Med. Chem.54 (6): 1789-811. [PMID:21332118]

4. Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, Menon S, Wang Z, Honda A, Pardee G et al.. (2014) Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat. Cell Biol.16 (11): 1069-79. [PMID:25327288]

5. Liu Q, Wang J, Kang SA, Thoreen CC, Hur W, Ahmed T, Sabatini DM, Gray NS. (2011) Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. J. Med. Chem.54 (5): 1473-80. [PMID:21322566]

6. Ronan B, Flamand O, Vescovi L, Dureuil C, Durand L, Fassy F, Bachelot MF, Lamberton A, Mathieu M, Bertrand T et al.. (2014) A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy. Nat. Chem. Biol.10 (12): 1013-9. [PMID:25326666]

7. Taracido IC, Harrington EM, Honda A, Keaney E. (2014) Bi-heteroaryl compounds as Vps34 inhibitors. Patent number: US8685993. Assignee: Novartis Ag. Priority date: 21/12/2010. Publication date: 01/04/2014.

How to cite this page

Phosphatidylinositol kinases: phosphatidylinositol 3-kinase catalytic subunit type 3. Last modified on 08/11/2016. Accessed on 24/03/2018. IUPHAR/BPS Guide to PHARMACOLOGY,