Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1800	Xp11.22	WNK3	WNK lysine deficient protein kinase 3
Mouse	-	1757	X F3	Wnk3	WNK lysine deficient protein kinase 3
Rat	-	1691	Xq21	Wnk3	WNK lysine deficient protein kinase 3

Previous and Unofficial Names

PRKWNK3

Database Links
Alphafold	Q9BYP7 (Hs), Q80XP9 (Mm)
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL6055 (Hs)
Ensembl Gene	ENSG00000196632 (Hs), ENSMUSG00000041245 (Mm), ENSRNOG00000002537 (Rn)
Entrez Gene	65267 (Hs), 279561 (Mm), 317420 (Rn)
Human Protein Atlas	ENSG00000196632 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:65267 (Hs), mmu:279561 (Mm), rno:317420 (Rn)
OMIM	300358 (Hs)
Pharos	Q9BYP7 (Hs)
RefSeq Nucleotide	NM_020922 (Hs), NM_001271678 (Mm), NM_001163607 (Rn)
RefSeq Protein	NP_065973 (Hs), NP_001258607 (Mm), NP_001157079 (Rn)
UniProtKB	Q9BYP7 (Hs), Q80XP9 (Mm)
Wikipedia	WNK3 (Hs)

Enzyme Reaction
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 2c [PMID: 24900538] Hs Inhibition 7.0 pIC50 3 ⤷ pIC50 7.0 (IC50 9.98x10-8 M) [3]

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 1-2
Key to terms and symbols		Click column headers to sort
Target used in screen: WNK3/WNK3
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM K-252a Hs Inhibitor Inhibition 60.3 70.0 8.0 staurosporine Hs Inhibitor Inhibition 73.6 83.5 40.0 Flt-3 inhibitor II Hs Inhibitor Inhibition 74.6 88.0 44.0 GSK-3 inhibitor XIII Hs Inhibitor Inhibition 74.9 74.0 31.0 aminopurvalanol A Hs Inhibitor Inhibition 76.9 88.0 37.0 compound 52 [PMID: 9677190] Hs Inhibitor Inhibition 77.7 88.0 57.0 dorsomorphin Hs Inhibitor Inhibition 78.1 107.0 91.0 isogranulatimide Hs Inhibitor Inhibition 79.1 74.0 45.0 indirubin derivative E804 Hs Inhibitor Inhibition 79.7 76.0 50.0 Cdk2 inhibitor IV Hs Inhibitor Inhibition 80.6 90.0 63.0
Displaying the top 10 most potent ligands  View all ligands in screen »