Cytokine receptor common β subunit

Target id: 2306

Nomenclature: Cytokine receptor common β subunit

Family: IL-3 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Cytokine receptor common β subunit has curated GtoImmuPdb data

Quaternary Structure: Complexes
Interleukin-3 receptor
Interleukin-5 receptor
Granulocyte macrophage colony-stimulating factor receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 897 22q12.3 CSF2RB colony stimulating factor 2 receptor beta common subunit
Mouse 1 896 15 37.36 cM Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Rat - - 7q34 Csf2rb colony stimulating factor 2 receptor beta common subunit
Previous and Unofficial Names
CD131 | GM-CSF/IL-3/IL-5 receptor common beta subunit | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Database Links
CATH/Gene3D
DrugBank Target
Ensembl Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
UniProtKB
Wikipedia
Immunopharmacology Comments
This a signal transducing protein subunit shared by the functional receptor heterodimers for the cytokines IL-3, IL-5 and GM-CSF, with each receptor having a unique ligand binding alpha subunit.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  cytokine receptor activity (GO:0004896) IEA
cellular response to interleukin-3 (GO:0036016) IEA
interleukin-5-mediated signaling pathway (GO:0038043) IEA
interleukin-3-mediated signaling pathway (GO:0038156) IEA
References: 

How to cite this page

IL-3 receptor family: Cytokine receptor common β subunit. Last modified on 22/03/2017. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2306.