Granulocyte macrophage colony-stimulating factor receptor

Target id: 2309

Nomenclature: Granulocyte macrophage colony-stimulating factor receptor

Family: IL-3 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Granulocyte macrophage colony-stimulating factor receptor has curated GtoImmuPdb data

Quaternary Structure: Subunits
GM-CSF receptor, α subunit (Ligand-binding subunit)
Cytokine receptor common β subunit (Other subunit)
Previous and Unofficial Names
GM-CSF receptor

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Agonists
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Ligand Sp. Action Affinity Units Reference
G-CSF {Sp: Human} Hs Agonist - -
GM-CSF {Sp: Human} Hs Agonist - -
Immunopharmacology Comments
The functional GM-CSF receptor is a heterodimer consisting of the ligand binding GM-CSF receptor α subunit (CSF2RA) and CSF2RB (cytokine receptor common β subunit). CSF2RB is required for the formation of the functional receptors for IL-3, IL-5 and GM-CSF.

How to cite this page

IL-3 receptor family: Granulocyte macrophage colony-stimulating factor receptor. Last modified on 22/03/2017. Accessed on 22/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2309.