Interleukin-27 receptor

Target id: 2316

Nomenclature: Interleukin-27 receptor

Family: IL-6 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-27 receptor has curated GtoImmuPdb data

Quaternary Structure: Subunits
Interleukin 27 receptor, alpha (Ligand-binding subunit)
Interleukin-6 receptor, β subunit (Other subunit)

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Agonists
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Ligand Sp. Action Affinity Units Reference
IL-27 {Sp: Human} Hs Agonist - -
Immunopharmacology Comments
The functional IL-27 receptor is a heterodimer of the ligand binding IL-27 receptor α subunit (IL27RA) and the IL-6 receptor signal transducing subunit (IL6ST) [2]. IL-27 receptor acts via the Th1 cell-specific transcription factor T-bet (TBX21) to control expression of interferon γ, and Th1 commitment [1].

References

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1. Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS, de Sauvage FJ. (2000) Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature407 (6806): 916-20. [PMID:11057672]

2. Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA. (2004) WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J. Immunol.172 (4): 2225-31. [PMID:14764690]

How to cite this page

IL-6 receptor family: Interleukin-27 receptor. Last modified on 07/04/2017. Accessed on 15/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2316.