acylaminoacyl-peptide hydrolase

Target id: 2328

Nomenclature: acylaminoacyl-peptide hydrolase

Family: S9: Prolyl oligopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for acylaminoacyl-peptide hydrolase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 732 3p21 APEH acylaminoacyl-peptide hydrolase
Mouse - 732 9 F2 Apeh acylpeptide hydrolase
Rat - 732 8q32 Apeh acylaminoacyl-peptide hydrolase
Previous and Unofficial Names
AARE | acyl-peptide hydrolase | APH | acylamino-acid-releasing enzyme
Database Links
Specialist databases
MEROPS S09.004 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.19.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
ARI-3099 Hs Inhibition 7.0 pIC50 1
pIC50 7.0 (IC50 1.04x10-7 M) [1]
Description: Substrate (Ac-Ala-AMC) assay.

References

Show »

1. Bachovchin DA, Koblan LW, Wu W, Liu Y, Li Y, Zhao P, Woznica I, Shu Y, Lai JH, Poplawski SE et al.. (2014) A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity. Nat. Chem. Biol.10 (8): 656-63. [PMID:24997602]

How to cite this page

S9: Prolyl oligopeptidase: acylaminoacyl-peptide hydrolase. Last modified on 20/07/2015. Accessed on 17/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2328.