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acylaminoacyl-peptide hydrolase

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Target not currently curated in GtoImmuPdb

Target id: 2328

Nomenclature: acylaminoacyl-peptide hydrolase

Family: S9: Prolyl oligopeptidase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 732 3p21.31 APEH acylaminoacyl-peptide hydrolase
Mouse - 732 9 59.07 cM Apeh acylpeptide hydrolase
Rat - 732 8q32 Apeh acylaminoacyl-peptide hydrolase
Previous and Unofficial Names Click here for help
AARE | acyl-peptide hydrolase | APH | acylamino-acid-releasing enzyme | APEH
Database Links Click here for help
Specialist databases
MEROPS S09.004 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ARI-3099 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.0 pIC50 1
pIC50 7.0 (IC50 1.04x10-7 M) [1]
Description: Substrate (Ac-Ala-AMC) assay.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Cellular signalling


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1. Bachovchin DA, Koblan LW, Wu W, Liu Y, Li Y, Zhao P, Woznica I, Shu Y, Lai JH, Poplawski SE et al.. (2014) A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity. Nat Chem Biol, 10 (8): 656-63. [PMID:24997602]

How to cite this page

S9: Prolyl oligopeptidase: acylaminoacyl-peptide hydrolase. Last modified on 20/07/2015. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY,