chymotrypsin C

Target id: 2341

Nomenclature: chymotrypsin C

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for chymotrypsin C in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 268 1p36.21 CTRC chymotrypsin C
Mouse - 268 4 E1 Ctrc chymotrypsin C (caldecrin)
Rat - 268 5q36 Ctrc chymotrypsin C
Previous and Unofficial Names
CLCR | ELA4 | elastase 4 | serum calcium-decreasing factor | chymotrypsin C (caldecrin)
Database Links
Specialist databases
MEROPS S01.157 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.2

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 20 [PMID: 12372533] Hs Inhibition 7.3 pKi 3
pKi 7.3 (Ki 5x10-8 M) [3]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Hereditary pancreatitis
Synonyms: Hereditary chronic pancreatitis [Orphanet: ORPHA676]
OMIM: 167800
Orphanet: ORPHA676
Disease:  Tropical pancreatitis
Orphanet: ORPHA103918
References:  1-2

References

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1. Derikx MH, Szmola R, te Morsche RH, Sunderasan S, Chacko A, Drenth JP. (2009) Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants. Eur J Gastroenterol Hepatol21 (8): 889-94. [PMID:19404200]

2. Paliwal S, Bhaskar S, Mani KR, Reddy DN, Rao GV, Singh SP, Thomas V, Chandak GR. (2013) Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants. Gut62 (11): 1602-6. [PMID:22580415]

3. Priestley ES, De Lucca I, Ghavimi B, Erickson-Viitanen S, Decicco CP. (2002) P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease. Bioorg. Med. Chem. Lett.12 (21): 3199-202. [PMID:12372533]

How to cite this page

S1: Chymotrypsin: chymotrypsin C. Last modified on 29/01/2016. Accessed on 14/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2341.