fibroblast activation protein alpha

Target id: 2365

Nomenclature: fibroblast activation protein alpha

Family: S9: Prolyl oligopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for fibroblast activation protein alpha in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 760 2q23 FAP fibroblast activation protein alpha
Mouse - 761 2 C1.3 Fap fibroblast activation protein
Rat - 761 3q21 Fap fibroblast activation protein, alpha
Previous and Unofficial Names
DPPIV | seprase
Database Links
Specialist databases
MEROPS S09.007 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 9 [PMID: 20718420] Hs Inhibition 7.7 pIC50 2
pIC50 7.7 (IC50 1.9x10-8 M) [2]
ARI-3099 Hs Inhibition 7.4 pIC50 1
pIC50 7.4 (IC50 3.6x10-8 M) [1]


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1. Poplawski SE, Lai JH, Li Y, Jin Z, Liu Y, Wu W, Wu Y, Zhou Y, Sudmeier JL, Sanford DG et al.. (2013) Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. J. Med. Chem., 56 (9): 3467-77. [PMID:23594271]

2. Tsai TY, Yeh TK, Chen X, Hsu T, Jao YC, Huang CH, Song JS, Huang YC, Chien CH, Chiu JH et al.. (2010) Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein. J. Med. Chem., 53 (18): 6572-83. [PMID:20718420]

How to cite this page

S9: Prolyl oligopeptidase: fibroblast activation protein alpha. Last modified on 09/04/2018. Accessed on 17/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY,