granzyme B

Target id: 2369

Nomenclature: granzyme B

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for granzyme B in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 247 14q11.2 GZMB granzyme B
Mouse - 247 14 D3 Gzmb granzyme B
Rat - 248 15p12 Gzmb granzyme B
Previous and Unofficial Names
cytotoxic serine protease B | CCP1 | CCP-1/C11 | CGL1 | CSPB | CTSGL1 | fragmentin | fragmentin 2 | GLP I | GLP III | GLP-1 | granzyme B(G,H) | GZB | HLP | natural killer cell protease 1 | RNKP-1 | SECT | granzyme-like protein 1 | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Database Links
Specialist databases
MEROPS S01.010 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.79

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 20 [PMID:12127536] Hs Inhibition 8.1 pKi 1
pKi 8.1 (Ki 7x10-9 M) [1]

References

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1. Willoughby CA, Bull HG, Garcia-Calvo M, Jiang J, Chapman KT, Thornberry NA. (2002) Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis. Bioorg. Med. Chem. Lett.12 (16): 2197-200. [PMID:12127536]

How to cite this page

S1: Chymotrypsin: granzyme B. Last modified on 29/01/2016. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2369.