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granzyme B

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Target not currently curated in GtoImmuPdb

Target id: 2369

Nomenclature: granzyme B

Family: S1: Chymotrypsin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 247 14q12 GZMB granzyme B
Mouse - 247 14 28.19 cM Gzmb granzyme B
Rat - 248 15p12 Gzmb granzyme B
Previous and Unofficial Names Click here for help
cytotoxic serine protease B | CCP1 | CCP-1/C11 | CGL1 | CSPB | CTSGL1 | fragmentin | fragmentin 2 | GLP I | GLP III | GLP-1 | granzyme B(G,H) | GZB | HLP | natural killer cell protease 1 | RNKP-1 | SECT | granzyme-like protein 1 | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Database Links Click here for help
Specialist databases
MEROPS S01.010 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.21.79

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 20 [PMID:12127536] Small molecule or natural product Primary target of this compound Hs Inhibition 8.1 pKi 1
pKi 8.1 (Ki 7x10-9 M) [1]
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0042267 natural killer cell mediated cytotoxicity IMP
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0001913 T cell mediated cytotoxicity IMP
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0001913 T cell mediated cytotoxicity IMP

References

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1. Willoughby CA, Bull HG, Garcia-Calvo M, Jiang J, Chapman KT, Thornberry NA. (2002) Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis. Bioorg Med Chem Lett, 12 (16): 2197-200. [PMID:12127536]

How to cite this page

S1: Chymotrypsin: granzyme B. Last modified on 29/01/2016. Accessed on 20/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2369.