kallikrein related peptidase 5

Target id: 2375

Nomenclature: kallikrein related peptidase 5

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for kallikrein related peptidase 5 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 293 19q13.33 KLK5 kallikrein related peptidase 5
Mouse - 293 7 B4 Klk5 kallikrein related-peptidase 5
Rat - - q22 Klk5 kallikrein related-peptidase 5
Previous and Unofficial Names
kallikrein 5 | kallikrein-5 | KLK-L2 | SCTE | kallikrein-related peptidase 5
Database Links
Specialist databases
MEROPS S01.017 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 3 [PMID: 23849879] Hs Inhibition 6.6 pIC50 1
pIC50 6.6 (IC50 2.7x10-7 M) [1]
compound 4d [PMID: 25489658] Hs Inhibition 6.0 pIC50 2
pIC50 6.0 (IC50 9.2x10-7 M) [2]

References

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1. Tan X, Furio L, Reboud-Ravaux M, Villoutreix BO, Hovnanian A, El Amri C. (2013) 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg. Med. Chem. Lett.23 (16): 4547-51. [PMID:23849879]

2. Tan X, Soualmia F, Furio L, Renard JF, Kempen I, Qin L, Pagano M, Pirotte B, El Amri C, Hovnanian A et al.. (2015) Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J. Med. Chem.58 (2): 598-612. [PMID:25489658]

How to cite this page

S1: Chymotrypsin: kallikrein related peptidase 5. Last modified on 29/01/2016. Accessed on 19/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2375.