legumain

Target id: 2380

Nomenclature: legumain

Family: C13: Legumain

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for legumain in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 433 14q32.12 LGMN legumain
Mouse - 435 12 E Lgmn legumain
Rat - 435 6q32 Lgmn legumain
Previous and Unofficial Names
AEP1 | LGMN1 | protease, cysteine 1 | Prsc1 | asparaginyl endopeptidase 1
Database Links
Specialist databases
MEROPS C13.004 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.22.34

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 7u [PMID: 24775305] Hs Inhibition 9.1 pIC50 1
pIC50 9.1 (IC50 9x10-10 M) [1]

References

Show »

1. Higgins C, Bouazzaoui S, Gaddale K, D'Costa Z, Templeman A, O'Rourke M, Young A, Scott C, Harrison T, Mullan P et al.. (2014) P3 SAR exploration of biphenyl carbamate based Legumain inhibitors. Bioorg. Med. Chem. Lett.24 (11): 2521-4. [PMID:24775305]

How to cite this page

C13: Legumain: legumain. Last modified on 23/07/2015. Accessed on 11/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2380.