proprotein convertase subtilisin/kexin type 2

Target id: 2383

Nomenclature: proprotein convertase subtilisin/kexin type 2

Family: S8: Subtilisin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for proprotein convertase subtilisin/kexin type 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 638 20p11.2 PCSK2 proprotein convertase subtilisin/kexin type 2
Mouse - 637 2 F3-H2 Pcsk2 proprotein convertase subtilisin/kexin type 2
Rat - 637 3q42 Pcsk2 proprotein convertase subtilisin/kexin type 2
Previous and Unofficial Names
NEC 2 | PC2 | Phpp-2 | prohormone convertase 2 | proprotein convertase 2 | SPC2 | neuroendocrine convertase 2
Database Links
Specialist databases
MEROPS S08.073 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
peptide 18 [PMID: 24350995] Hs Inhibition 9.6 pKi 1
pKi 9.6 (Ki 2.4x10-10 M) [1]


Show »

1. Kwiatkowska A, Couture F, Levesque C, Ly K, Desjardins R, Beauchemin S, Prahl A, Lammek B, Neugebauer W, Dory YL et al.. (2014) Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J. Med. Chem.57 (1): 98-109. [PMID:24350995]

How to cite this page

S8: Subtilisin: proprotein convertase subtilisin/kexin type 2. Last modified on 27/07/2015. Accessed on 22/03/2018. IUPHAR/BPS Guide to PHARMACOLOGY,