S8: Subtilisin C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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One member of this family has garnered intense interest as a clinical drug target. As liver PCSK9 acts to maintain cholesterol homeostasis, it has become a target of intense interest for clinical drug development. Inhibition of PCSK9 can lower low-density cholesterol (LDL-C) by clearing LDLR-bound LDL particles, thereby lowering circulating cholesterol levels. It is hypothesised that this action may improve outcomes in patients with atherosclerotic cardiovascular disease [4-6]. Therapeutics which inhibit PCSK9 are viewed as potentially lucrative replacements for statins, upon statin patent expiry. Several monoclonal antibodies including alirocumab, evolocumab, bococizumab, RG-7652 and LY3015014 are under development. One RNAi therapeutic, code named ALN-PCS02, is also in development [1-3].

Enzymes

furin, paired basic amino acid cleaving enzyme Show summary » More detailed page

membrane bound transcription factor peptidase, site 1 Show summary » More detailed page

proprotein convertase subtilisin/kexin type 1 Show summary » More detailed page

proprotein convertase subtilisin/kexin type 2 Show summary » More detailed page

proprotein convertase subtilisin/kexin type 4 Show summary » More detailed page

proprotein convertase subtilisin/kexin type 5 Show summary » More detailed page

proprotein convertase subtilisin/kexin type 6 Show summary » More detailed page

proprotein convertase subtilisin/kexin type 7 Show summary » More detailed page

proprotein convertase subtilisin/kexin type 9 Show summary » More detailed page

tripeptidyl peptidase 2 Show summary » More detailed page

References

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How to cite this family page

Database page citation:

S8: Subtilisin. Accessed on 18/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=755.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.