proprotein convertase subtilisin/kexin type 6

Target id: 2386

Nomenclature: proprotein convertase subtilisin/kexin type 6

Family: S8: Subtilisin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for proprotein convertase subtilisin/kexin type 6 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 969 15q26 PCSK6 proprotein convertase subtilisin/kexin type 6
Mouse - 959 7 C Pcsk6 proprotein convertase subtilisin/kexin type 6
Rat - 937 1q22 Pcsk6 proprotein convertase subtilisin/kexin type 6
Previous and Unofficial Names
subtilisin-like proprotein convertase 4 | kexin-like protease PC7A | pace4 | Spc4 | paired basic amino acid cleaving system 4
Database Links
Specialist databases
MEROPS S08.075 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide Hs Inhibition 9.2 pKi 1
pKi 9.2 (Ki 6x10-10 M) [1]
peptide 18 [PMID: 24350995] Hs Inhibition 8.5 pKi 2
pKi 8.5 (Ki 3.1x10-9 M) [2]
multi-Leu (ML)-peptide Hs Inhibition 7.7 pKi 3
pKi 7.7 (Ki 1.8x10-8 M) [3]
furin inhibitor peptide Hs Inhibition 6.8 pKi 4
pKi 6.8 (Ki 1.62x10-7 M) [4]


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1. Becker GL, Sielaff F, Than ME, Lindberg I, Routhier S, Day R, Lu Y, Garten W, Steinmetzer T. (2010) Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. J. Med. Chem.53 (3): 1067-75. [PMID:20038105]

2. Kwiatkowska A, Couture F, Levesque C, Ly K, Desjardins R, Beauchemin S, Prahl A, Lammek B, Neugebauer W, Dory YL et al.. (2014) Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J. Med. Chem.57 (1): 98-109. [PMID:24350995]

3. Levesque C, Fugère M, Kwiatkowska A, Couture F, Desjardins R, Routhier S, Moussette P, Prahl A, Lammek B, Appel JR et al.. (2012) The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells. J. Med. Chem.55 (23): 10501-11. [PMID:23126600]

4. Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R et al.. (2007) Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J. Biol. Chem.282 (29): 20847-53. [PMID:17537721]

How to cite this page

S8: Subtilisin: proprotein convertase subtilisin/kexin type 6. Last modified on 28/07/2015. Accessed on 24/03/2018. IUPHAR/BPS Guide to PHARMACOLOGY,