proprotein convertase subtilisin/kexin type 1

Target id: 2382

Nomenclature: proprotein convertase subtilisin/kexin type 1

Family: S8: Subtilisin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for proprotein convertase subtilisin/kexin type 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 753 5q15-q21 PCSK1 proprotein convertase subtilisin/kexin type 1
Mouse - 753 13 C2 Pcsk1 proprotein convertase subtilisin/kexin type 1
Rat - 752 2q11-q12 Pcsk1 proprotein convertase subtilisin/kexin type 1
Previous and Unofficial Names
neuroendocrine convertase 1 | prohormone convertase 1 | BDP | NEC1 | PC1 | PC3 | Phpp-1 | prohormone convertase 3 | propeptide-processing protease | SPC3
Database Links
Specialist databases
MEROPS S08.072 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.21.93

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide Hs Inhibition 9.1 pKi 1
pKi 9.1 (Ki 7.5x10-10 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Obesity due to prohormone convertase I deficiency
OMIM: 600955, 612362
Orphanet: ORPHA71528

References

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1. Becker GL, Sielaff F, Than ME, Lindberg I, Routhier S, Day R, Lu Y, Garten W, Steinmetzer T. (2010) Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. J. Med. Chem.53 (3): 1067-75. [PMID:20038105]

How to cite this page

S8: Subtilisin: proprotein convertase subtilisin/kexin type 1. Last modified on 28/07/2015. Accessed on 14/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2382.