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proprotein convertase subtilisin/kexin type 1

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Target not currently curated in GtoImmuPdb

Target id: 2382

Nomenclature: proprotein convertase subtilisin/kexin type 1

Family: S8: Subtilisin

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 753 5q15 PCSK1 proprotein convertase subtilisin/kexin type 1
Mouse - 753 13 40.63 cM Pcsk1 proprotein convertase subtilisin/kexin type 1
Rat - 752 2q23 Pcsk1 proprotein convertase subtilisin/kexin type 1
Previous and Unofficial Names Click here for help
neuroendocrine convertase 1 | prohormone convertase 1 | BDP | NEC1 | PC1 | PC3 | Phpp-1 | prohormone convertase 3 | propeptide-processing protease | SPC3
Database Links Click here for help
Specialist databases
MEROPS S08.072 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.21.93

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide Small molecule or natural product Click here for species-specific activity table Hs Inhibition 9.1 pKi 1
pKi 9.1 (Ki 7.5x10-10 M) [1]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0070555 response to interleukin-1 IEP
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Obesity due to prohormone convertase I deficiency
OMIM: 600955, 612362
Orphanet: ORPHA71528

References

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1. Becker GL, Sielaff F, Than ME, Lindberg I, Routhier S, Day R, Lu Y, Garten W, Steinmetzer T. (2010) Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. J Med Chem, 53 (3): 1067-75. [PMID:20038105]

How to cite this page

S8: Subtilisin: proprotein convertase subtilisin/kexin type 1. Last modified on 28/07/2015. Accessed on 18/06/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2382.