tripeptidyl peptidase 2

Target id: 2423

Nomenclature: tripeptidyl peptidase 2

Family: S8: Subtilisin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for tripeptidyl peptidase 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1249 13q32-q33 TPP2 tripeptidyl peptidase 2
Mouse - 1262 1 C1.1 Tpp2 tripeptidyl peptidase II
Rat - 1249 9q22 Tpp2 tripeptidyl peptidase 2
Previous and Unofficial Names
TppII | tripeptidyl aminopeptidase
Database Links
Specialist databases
MEROPS S08.090 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.14.10

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
example 8 [WO1999033801A1] Hs Inhibition 9.4 pKi 1
pKi 9.4 (Ki 3.6x10-10 M) [1]
peptide 4 [PMID: 18294843] Hs Inhibition 7.7 pKi 2
pKi 7.7 (Ki 2x10-8 M) [2]

References

Show »

1. Chen Y, Ganellin CR, Rose C, Samad S, Schwartz J-C, Vargas F, Zhao L. (1999) Tripeptidyl peptidase inhibitors. Patent number: WO1999033801 A1. Assignee: Inst Nat Sante Rech Med, Chen Y, Ganellin CR, Rose C, Samad S, Schwartz J-C, Vargas F, Zhao L. Priority date: 23/12/1998. Publication date: 08/07/1999.

2. Levengood MR, van der Donk WA. (2008) Use of lantibiotic synthetases for the preparation of bioactive constrained peptides. Bioorg. Med. Chem. Lett.18 (10): 3025-8. [PMID:18294843]

How to cite this page

S8: Subtilisin: tripeptidyl peptidase 2. Last modified on 16/07/2015. Accessed on 18/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2423.