tripeptidyl peptidase 2

Target id: 2423

Nomenclature: tripeptidyl peptidase 2

Family: S8: Subtilisin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for tripeptidyl peptidase 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1249 13q32-q33 TPP2 tripeptidyl peptidase 2
Mouse - 1262 1 C1.1 Tpp2 tripeptidyl peptidase II
Rat - 1249 9q22 Tpp2 tripeptidyl peptidase 2
Previous and Unofficial Names
TppII | tripeptidyl aminopeptidase
Database Links
Specialist databases
MEROPS S08.090 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
example 8 [WO1999033801A1] Hs Inhibition 9.4 pKi 1
pKi 9.4 (Ki 3.6x10-10 M) [1]
peptide 4 [PMID: 18294843] Hs Inhibition 7.7 pKi 2
pKi 7.7 (Ki 2x10-8 M) [2]


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1. Chen Y, Ganellin CR, Rose C, Samad S, Schwartz J-C, Vargas F, Zhao L. (1999) Tripeptidyl peptidase inhibitors. Patent number: WO1999033801 A1. Assignee: Inst Nat Sante Rech Med, Chen Y, Ganellin CR, Rose C, Samad S, Schwartz J-C, Vargas F, Zhao L. Priority date: 23/12/1998. Publication date: 08/07/1999.

2. Levengood MR, van der Donk WA. (2008) Use of lantibiotic synthetases for the preparation of bioactive constrained peptides. Bioorg. Med. Chem. Lett.18 (10): 3025-8. [PMID:18294843]

How to cite this page

S8: Subtilisin: tripeptidyl peptidase 2. Last modified on 16/07/2015. Accessed on 17/03/2018. IUPHAR/BPS Guide to PHARMACOLOGY,