peptidase D

Target id: 2389

Nomenclature: peptidase D

Family: M24: Methionyl aminopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for peptidase D in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 493 19q13.11 PEPD peptidase D
Mouse - 493 7 B1 Pepd peptidase D
Rat - 492 1q21 Pepd peptidase D
Previous and Unofficial Names
imidodipeptidase | Pep4 | peptidase 4 | prolidase | proline dipeptidase
Database Links
Specialist databases
MEROPS M24.007 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
phosphoenolpyruvic acid Pig Inhibition 9.5 – 9.6 pKi 1
pKi 9.5 – 9.6 (Ki 3x10-10 – 2.4x10-10 M) [1]
Description: Biphasic inhibition of purified enzyme from pig kidney.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Prolidase deficiency
OMIM: 170100
Orphanet: ORPHA742


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1. Mock WA, Liu Y. (1995) Inhibition of prolidase by phosphoenolpyruvate is biphasic. avoidance of endogenous-metabolite inactivation by cooperativity within an enzyme dimer. Bioorganic & Medicinal Chemistry Letters.5 (6): 627-630.

How to cite this page

M24: Methionyl aminopeptidase: peptidase D. Last modified on 22/07/2015. Accessed on 19/03/2018. IUPHAR/BPS Guide to PHARMACOLOGY,